Histopathological study of canine sebaceous tumors and their association with PCNA expression by immunohistochemistry

Autores

  • Fabíola Barroso Costa Universidade Federal Fluminense; Universidade Federal de Minas Gerais
  • Kássia Valéria Gomes Coelho da Silva Universidade Federal Fluminense
  • Juliana da Silva Leite Universidade Federal Fluminense
  • Franciele Basso Fernandes Silva Universidade Federal Fluminense
  • Baárbara Paula dos Santos Batista Universidade Federal Fluminense
  • Juliana Freitas de Melo Universidade Federal de Minas Gerais
  • Ana Maria Reis Ferreira Universidade Federal Fluminense

Palavras-chave:

adenoma, dogs, imunohistochemistry, sebaceous gland neoplasms

Resumo

Sebaceous tumors are common in dogs and include benign and malignant lesions. The increase in immunohistochemical evaluation of sebaceous tumors aggregates information regarding the origin and degree of malignancy of the lesions. The objective of this study was to evaluate PCNA immunohistochemical expression of  sebaceous tumors in dogs. Sixty-one samples include normal skin and sebaceous tumors were selected from dogs of various breeds and ages, no gender predilection, sent to the Veterinary Pathology Service of Universidade Federal Fluminense, Niterói/RJ, Brazil. Samples passed through histological processing, routine staining and immunostaining from PCNA. Descriptive statistical analysis, Wilcoxon-Mann-Whitney and Fisher’s exact test were performed. The mean age of the affected animals was 10.56 years. There was no sexual predilection. Breeds more frequently affected were: Poodles, mixed-breed dogs and Cocker Spaniels. Most of the tumors were neoplasms (67.27%), and 75.67% of those were benign. Sebaceous adenoma was the most frequent neoplasm (56.75%). PCNA immunoexpression was present in hyperplasia, benign and malignant tumors. No previous studies were found using PCNA antibody in sebaceous tumors of dogs. Thus, more studies are needed to provide greater clarity regarding the role of these markers on normal skin and sebaceous tumors of dogs, as well as their use as prognostic factors of malignant sebaceous tumors, assisting in diagnosis and therapeutic orientation.

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Biografia do Autor

Fabíola Barroso Costa, Universidade Federal Fluminense; Universidade Federal de Minas Gerais

Departamento de Patologia e Clínica Veterinária, área de Patologia Animal

Kássia Valéria Gomes Coelho da Silva, Universidade Federal Fluminense

Departamento de Patologia e Clínica Veterinária, área de Patologia Animal

Juliana da Silva Leite, Universidade Federal Fluminense

Departamento de Patologia e Clínica Veterinária, área de Patologia Animal

Franciele Basso Fernandes Silva, Universidade Federal Fluminense

Departamento de Patologia e Clínica Veterinária, área de Patologia Animal

Baárbara Paula dos Santos Batista, Universidade Federal Fluminense

Departamento de Patologia e Clínica Veterinária, área de Patologia Animal

Juliana Freitas de Melo, Universidade Federal de Minas Gerais

Departamento de Estatística

Ana Maria Reis Ferreira, Universidade Federal Fluminense

Departamento de Patologia e Clínica Veterinária, área de Patologia Animal

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Publicado

2020-12-09

Edição

Seção

Patologia e Análises Clínica Veterinária