Alterações hematológicas em cadelas portadoras de tumores de mama

Abstract

In this study we describe the occurrence of hematological disorders in bitches with mammary neoplasm and analyze the possibility that alterations present can be used as a diagnostic parameter and prognosis. Two hundred and forty-six dogs with mammary neoplasms (123 with malignant and 123 with benign mammary tumor) and the same number of female dogs without mammary tumors were investigated for observation of hematologic abnormalities. The full blood test and measurement of proteins was carried out before any treatment for breast tumor. The diagnosis of mammary neoplasm was done by histopathology. Few animals with benign tumors had hematological disorders, but in malignant neoplasm the prevalence was 55%, and thrombocytosis, hyperproteinemia (hypergammaglobulinemia) and leucopenia (neutropenia) were the most prevalent abnormalities. Anemia and erythrocytosis had equilibrated occurrence (22 and 21%, respectively). Leukocytosis and thrombocytopenia were less hematologic changes observed. We concluded that because of the high prevalence of thrombocytosis, leukopenia and hyperproteinemia (hypergammaglobulinemia) in bitches bearing mammary tumors, the hematological abnormalities may be signaling of malignant neoplasm.